期刊
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
卷 63, 期 2, 页码 147-151出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAI.0b013e31828f93bb
关键词
inflammasome; SNPs; HIV-1; tuberculosis; HIV-TB coinfection; HIV-associated opportunistic infections
资金
- Pernambuco Research Foundation (FACEPE) [APQ-0757-2.02/10]
- Sao Paulo Research foundation (FAPESP) [09/53575-5]
- Brazilian National Council of Research and Technology (CNPq) [311949/2011-8]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [09/53575-5] Funding Source: FAPESP
HLA and other genetic variants, playing an important role in innate and adaptive immunity, are known to influence tuberculosis (TB) development in HIV-1-positive (HIV+) patients. Because inflammasome genes contribute to HIV-1 susceptibility, we investigated the possible association between polymorphisms in inflammasome genes with HIV-1 and Mycobacterium tuberculosis coinfection (HIV+ TB+) in a case/control cohort of Brazilian individuals. Nineteen single-nucleotide polymoprhims in 8 inflammasome genes (NLRP1, NLRP3, AIM2, CARD8, CASP1, IL1B, IL1R, and HSP90) were analyzed in HIV+ TB+ Brazilian patients (from Recife, Pernambuco). CARD8 rs6509365 polymorphism was associated with HIV+ TB+ (P = 5 x 10(-5)), suggesting a predisposing role of this variant in M. tuberculosis susceptibility in HIV+ subjects (odds ratio = 2.45). This effect is even strong when this allele is combined to CARD8 rs2043211 single-nucleotide polymoprhim. The results of this study support the novel association between CARD8 gene and HIV+ TB+ coinfection, demonstrating that inflammasome genetics could influence HIV-1 infection and the development of opportunistic infection.
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