期刊
MOLECULES
卷 20, 期 12, 页码 22044-22057出版社
MDPI
DOI: 10.3390/molecules201219828
关键词
6-aminopenicillanic acid (6-APA); 2-azetidinone; beta-lactam antibiotics; antibacterial; Staudinger reaction
资金
- Ministero dell'Istruzione, dell'Universita e dellaRicerca (MIUR)
- Centro di Tecnologie Integrate per la Salute [PONa3_00138]
- Universita di Salerno
The synthesis and the biological activity of novel semi-synthetic -lactam compounds containing an azetidinone moiety joined to the amino-nitrogen of the (+)-6-aminopenicillanic acid (6-APA) as new antibacterial agents is reported. The synthesized compounds were screened for their in vitro antimicrobial activity against a panel of Gram positive and Gram negative pathogens and environmental bacteria. Tested compounds displayed good antimicrobial activity against all tested Gram positive bacteria and for Staphylococcus aureus and Staphylococcus epidermidis antimicrobial activity resulted higher than that of the reference antibiotic. Additionally, in vitro cytotoxic screening was also carried out indicating that the compounds do not cause a cell vitality reduction effective at concentration next to and above those shown to be antimicrobial.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据