期刊
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
卷 60, 期 3, 页码 244-248出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAI.0b013e31825a313c
关键词
PML; PD-1; immune exhaustion; immunotherapy
资金
- Harvard Catalyst
- Harvard Clinical and Translational Science Center (NIH) [UL1 RR 025758]
- Harvard University
- NIH [R01 NS 047029, NS 041198, K24 NS 060950, K08 NS 064215-01, T32 AI07387-21]
- Pfizer Inc.
- Merck Co.
The cellullar immune response is important in the containment of progressive multifocal leukoencephalopathy (PML). We examined program cell death-1 (PD-1) expression, a marker of cellular immune exhaustion, on T lymphocytes in PML. PD-1 expression was elevated on total CD4(+) and CD8(+) T cells (medians 36% and 24%) in PML patients compared with healthy control subjects (medians 14% and 18%; P = 0.0015 and P = 0.033). In PML patients, JC virus (JCV)-specific CD8(+) cytotoxic T lymphocytes expressed PD-1 more frequently than total CD8(+) T lymphocytes (means 39% and 78%, P = 0.0004). Blocking the PD-1 receptor increased JCV-specific T-cell immune response in a subgroup of PML patients.
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