期刊
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
卷 59, 期 3, 页码 325-328出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAI.0b013e31823fdbec
关键词
children and young adults; clusters; heat maps; metabolic abnormalities
资金
- Statistical and Data Analysis Center at Harvard School of Public Health, under the National Institute of Allergy and Infectious Diseases with the Pediatric AIDS Clinical Trials Group [5 U01 AI41110]
- Statistical and Data Analysis Center at Harvard School of Public Health, under the National Institute of Allergy and Infectious Diseases with the IMPAACT Group [1 U01 AI068616]
- National Institute of Allergy and Infectious Diseases (NIAID) [U01 AI068632]
- NICHD International and Domestic Pediatric and Maternal HIV Clinical Trials Network
- NICHD [N01-DK-9-001/HHSN267200800001C]
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- National Institute of Mental Health (NIMH) [AI068632]
- P1045 protocol team
Cluster heat maps were used to investigate relationships between body composition, lipid levels, and glucose metabolism in HIV-infected and HIV-uninfected children and young adults using data from a cross-sectional study. Three distinct clusters of participants were identified. One group had lower body fat and higher lipid measures and was mostly HIV infected. The other 2 groups were a mix of HIV-infected and HIV-uninfected participants. Of these, 1 cluster had more participants with higher body fat and insulin resistance, which are risk factors for future cardiovascular disease, and the other had relatively normal measurements on all outcomes.
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