期刊
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
卷 48, 期 3, 页码 281-288出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAI.0b013e31817bbbf0
关键词
HIV-1 infection; nuclear magnetic resonance spectroscopy; lipoprotein subclasses; dyslipidemia; antiretroviral drugs
资金
- NCRR NIH HHS [5-M01-RR-00722] Funding Source: Medline
- NIAID NIH HHS [U01-AI-35040, U01-AI-35041, U01-AI-35042, U01-AI-35043, U01-AI-37613, U01-AI-37984, U01-AI-35039] Funding Source: Medline
Background: Alterations in serum lipids and an increased risk of myocardial infarction have been associated with HIV-1 infection and its treatment. Methods: Lipoprotein subclasses were measured by nuclear magnetic resonance spectroscopy in frozen plasma samples from participants in the Multicenter AIDS Cohort Study. The effects of HIV-1 infection, antiretroviral therapy, and other factors on median particle concentrations were examined using quantile regression. Results: Fasted samples were tested from 1082 men, including 609 HIV-seronegative and 473 HIV-1-infected men. Compared with HIV-seronegative men, HIV-1-infected men on antiretroviral therapy had an atherogenic phenotype with higher numbers of very low density lipoprotein and small low-density lipoprotein particles and lower numbers of high-density lipoprotein and large low-density lipoprotein particles. HIV-infected, antiretroviral-naive men had significantly lower high-density lipoprotein and small low-density lipoprotein particle concentrations compared with the HIV-seronegative men. Among men on antiretroviral therapy, the atherogenic phenotype was most pronounced in men with a good clinical status. Conclusion: Use of antiretroviral therapy in HIV-1-infected men was associated with an atherogenic lipoprotein phenotype.
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