期刊
MOLECULES
卷 20, 期 1, 页码 1424-1433出版社
MDPI AG
DOI: 10.3390/molecules20011424
关键词
Diphylleia sinensis L; Aspergillus fumigates; indolediketopiperazine alkaloids; steroid; cytotoxicity
资金
- National Science Foundation of China [81173505]
- Ministry of Science and Technology of China [2012BAC01B05-7]
Two new compounds, fumitremorgin 12-methoxy-13-[5'-hydroxy-2'-(1''-hydroxy-3''-methoxy-5''-methylbenzoyl)-3'-methoxy]benzoic acid methyl ester (fumitremorgin D, 1) and 4,8,10,14-tetramethyl-6-acetoxy-14-[16-acetoxy-19-(20,21-dimethyl)-18-ene]-phenanthrene-1-ene-3,7-dione (2) were isolated from the cultured endophytic isolated fungus Aspergillus fumigatus, together with fourteen known compounds. Their structures were elucidated by 1-D and 2-D NMR analyses. The cytotoxicity profile of the compound against the human hepatocellular carcinoma cell line HepG2 was evaluated by MTT antiproliferative assays.
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