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JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
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The Induction of KLF5 Transcription Factor by Progesterone Contributes to Progesterone-Induced Breast Cancer Cell Proliferation and Dedifferentiation
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Overexpression of angiotensin II type 2 receptor suppresses neointimal hyperplasia in a rat carotid arterial balloon injury model
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Deregulated expression of Kruppel-like factors in acute myeloid leukemia
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Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF)
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
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Kruppel-like factor (KLF) 5 mediates cyclin D1 expression and cell proliferation via interaction with c-Jun in Ang II-induced VSMCs
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Kruppel-Like Factor 5 Is Not Required for K-RasG12D Lung Tumorigenesis, but Represses ABCG2 Expression and Is Associated with Better Disease-Specific Survival
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AMERICAN JOURNAL OF PATHOLOGY (2010)
Phenotypic Modulation of Vascular Smooth Muscle Cells
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Annals of the New York Academy of Sciences (2010)
Direct targets of Klf5 transcription factor contribute to the maintenance of mouse embryonic stem cell undifferentiated state
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BMC BIOLOGY (2010)
Kruppel-like transcription factors and control of pluripotency
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BMC BIOLOGY (2010)
The Fbw7 Tumor Suppressor Targets KLF5 for Ubiquitin-Mediated Degradation and Suppresses Breast Cell Proliferation
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CANCER RESEARCH (2010)
Estrogen-induced interaction between KLF5 and estrogen receptor (ER) suppresses the function of ER in ER-positive breast cancer cells
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INTERNATIONAL JOURNAL OF CANCER (2010)
The Fbw7/Human CDC4 Tumor Suppressor Targets Proproliferative Factor KLF5 for Ubiquitination and Degradation through Multiple Phosphodegron Motifs
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JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Kruppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined ApcMin and KRASV12 mutations
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Mammalian Kruppel-Like Factors in Health and Diseases
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KLF5 enhances SREBP-1 action in androgen-dependent induction of fatty acid synthase in prostate cancer cells
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BIOCHEMICAL JOURNAL (2009)
Haploinsufficiency of Kruppel-Like Factor 5 Rescues the Tumor-Initiating Effect of the ApcMin Mutation in the Intestine
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CANCER RESEARCH (2009)
Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases
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CELLULAR AND MOLECULAR LIFE SCIENCES (2009)
Synthetic retinoid Am80 inhibits interaction of KLF5 with RARα through inducing KLF5 dephosphorylation mediated by the PI3K/Akt signaling in vascular smooth muscle cells
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FEBS LETTERS (2009)
Angiotensin II Stimulates KLF5 Phosphorylation and its Interaction with c-Jun Leading to Suppression of p21 Expression in Vascular Smooth Muscle Cells
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JOURNAL OF BIOCHEMISTRY (2009)
Pro-proliferative Factor KLF5 Becomes Anti-proliferative in Epithelial Homeostasis upon Signaling-mediated Modification
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JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
KLF5 Promotes Breast Cell Survival Partially through Fibroblast Growth Factor-binding Protein 1-pERK-mediated Dual Specificity MKP-1 Protein Phosphorylation and Stabilization
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JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Acetylation of KLF5 Alters the Assembly of p15 Transcription Factors in Transforming Growth Factor-β-mediated Induction in Epithelial Cells
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JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Opposing Effects of KLF5 on the Transcription of MYC in Epithelial Proliferation in the Context of Transforming Growth Factor β
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Kruppel-like Factor 5 Shows Proliferation-specific Roles in Vascular Remodeling, Direct Stimulation of Cell Growth, and Inhibition of Apoptosis
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Up-Regulation of Kruppel-Like Factor 5 in Pancreatic Cancer Is Promoted by Interleukin-1β Signaling and Hypoxia-Inducible Factor-1α
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Induction of Kruppel-Like Factor 5 Expression by Androgens Results in Increased CXCR4-Dependent Migration of Prostate Cancer Cells in Vitro
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Kruppel-like factor 5 promotes breast cell proliferation partially through upregulating the transcription of broblast growth factor binding protein 1
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Kruppel-like factor 5 is required for perinatal lung morphogenesis and function
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DEVELOPMENT (2008)
Acyclic retinoid inhibits functional interaction of transcription factors Kruppel-like factor 5 and retinoic acid receptor-alpha
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FEBS LETTERS (2008)
Kruppel-like factor 5 mediates cellular transformation during oncogenic KRAS-induced intestinal tumorigenesis
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Kruppel-like factor 5 mediates transmissible murine colonic hyperplasia caused by Citrobacter rodentium infection
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GASTROENTEROLOGY (2008)
Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9
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Kruppel-like factor 5 controls keratinocyte migration via the integrin-linked kinase
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SUMOylation Regulates Nuclear Localization of Kruppel-like Factor 5
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JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
A core Klf circuitry regulates self-renewal of embryonic stem cells
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NATURE CELL BIOLOGY (2008)
SUMOylation of Kruppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-δ
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NATURE MEDICINE (2008)
Expression of Kruppel-like factor 5 gene in human brain and association of the gene with the susceptibility to schizophrenia
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Promoter region-specific histone incorporation by the novel histone chaperone ANP32B and DNA-binding factor KLF5
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MOLECULAR AND CELLULAR BIOLOGY (2008)
Kruppel-like factor 5 modulates p53-independent apoptosis through Pim1 survival kinase in cancer cells
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The diverse functions of Kruppel-like factors 4 and 5 in epithelial biology and pathobiology
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BIOESSAYS (2007)
Overexpression of Kruppel-like factor 5 in esophageal epithelia in vivo leads to increased proliferation in basal but not suprabasal cells
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Functional interaction between the transcription factor Kruppel-like factor 5 and poly(ADP-ribose) polymerase-1 in cardiovascular apoptosis
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JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Proteasomal degradation of the KLF5 transcription factor through a ubiquitin-independent pathway
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FEBS LETTERS (2007)
Protein inhibitor of activated STAT1 interacts with and up-regulates activities of the pro-proliferative transcription factor Kruppel-like factor 5
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JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Kruppel-like factor 5 activates MEK/ERK signaling via EGFR in primary squamous epithelial cells
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FASEB JOURNAL (2007)
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ONCOGENE (2006)
Epidermal and craniofacial defects in mice overexpressing Klf5 in the basal layer of the epidermis
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Angiotensin II and tumor necrosis factor-alpha upregulate survivin and Kruppel-like factor 5 in smooth muscle cells: Potential relevance to vein graft hyperplasia
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KLF5 interacts with p53 in regulating survivin expression in acute lymphoblastic leukemia
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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Expression of KLF5 is a prognostic factor for disease-free survival and overall survival in patients with breast cancer
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CLINICAL CANCER RESEARCH (2006)
KLF5 promotes cell proliferation and tumorigenesis through gene regulation in the TSU-Pr1 human bladder cancer cell line
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INTERNATIONAL JOURNAL OF CANCER (2006)
Kruppel-like factor 5 is an important mediator for lipopolysaccharide-induced proinflammatory response in intestinal epithelial cells
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Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells
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JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Synthetic retinoid Am80 suppresses smooth muscle phenotypic modulation and in-stent neointima formation by inhibiting KLF5
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Microarray analysis to identify molecular mechanisms of radiation-induced microvascular damage in normal tissues
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All-trans retinoic acid inhibits proliferation of intestinal epithelial cells by inhibiting expression of the gene encoding Kruppel-like factor 5
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FEBS LETTERS (2004)
Regulation of T-cell receptor Dβ1 promoter by KLF5 through reiterated GC-rich motifs
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BLOOD (2003)
KLF5 is frequently deleted and down-regulated but rarely mutated in prostate cancer
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PROSTATE (2003)
Phosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function
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NUCLEIC ACIDS RESEARCH (2003)
Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain
S Miyamoto et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Sp1-and Kruppel-like transcription factors
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GENOME BIOLOGY (2003)
A possible tumor suppressor role of the KLF5 transcription factor in human breast cancer
C Chen et al.
ONCOGENE (2002)
Human Kruppel-like factor5/KLF5:: Synergy with NF-κB/Rel factors and expression in human skin and hair follicles
I Sur et al.
EUROPEAN JOURNAL OF CELL BIOLOGY (2002)
Kruppel-like factors: Three fingers in many pies
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JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Unanticipated repression function linked to erythroid Kruppel-like factor
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Intestinal-enriched Kruppel-like factor (Kruppel-like factor 5) is a positive regulator of cellular proliferation
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Positive- and negative-acting Kruppel-like transcription factors bind a transforming growth factor β control element required for expression of the smooth muscle cell differentiation marker SM22α in vivo
PJ Adam et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Somatic deletions in hereditary breast cancers implicate 13q21 as a putative novel breast cancer susceptibility locus
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