期刊
IUBMB LIFE
卷 65, 期 6, 页码 479-486出版社
WILEY
DOI: 10.1002/iub.1157
关键词
striated muscle; cardiac hypertrophy; breast cancer; OBSCN; obscurin; UNC-89
资金
- NHLBI NIH HHS [K99 HL116778] Funding Source: Medline
- NIAMS NIH HHS [T32 AR007592] Funding Source: Medline
Discovered about a decade ago, obscurin (similar to 720 kDa) is a member of a family of giant proteins expressed in striated muscle that are essential for normal muscle function. Much of what we understand about obscurin stems from its functions in cardiac and skeletal muscle. However, recent evidence has indicated that variants of obscurin(obscurins) are expressed in diverse cell types, where they contribute to distinct cellular processes. Dysfunction or abrogation of obscurins has also been implicated in the development of several pathological conditions, including cardiac hypertrophy and cancer. Herein, we present an overview of obscurins with an emphasis on novel findings that demonstrate their heretofore-unsuspected importance in cell signaling and disease progression. (C) 2013 IUBMB Life,
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