期刊
IUBMB LIFE
卷 64, 期 10, 页码 809-816出版社
WILEY-BLACKWELL
DOI: 10.1002/iub.1075
关键词
alternative splicing; eukaryotic gene expression; pre-mRNA processing; protein function; protein expression
资金
- Agencia Nacional de Promocion Cientifica y Tecnologica of Argentina (ANPCyT)
- University of Buenos Aires, Argentina (UBACyT)
- European Alternative Splicing Network (EURASNET)
- Consejo Nacional de Investigaciones Cientificas y Tecnicas of Argentina (CONICET)
Serine/arginine-rich (SR) proteins are among the most studied splicing regulators. They constitute a family of evolutionarily conserved proteins that, apart from their initially identified and deeply studied role in splicing regulation, have been implicated in genome stability, chromatin binding, transcription elongation, mRNA stability, mRNA export and mRNA translation. Remarkably, this list of SR protein activities seems far from complete, as unexpected functions keep being unraveled. An intriguing aspect that awaits further investigation is how the multiple tasks of SR proteins are concertedly regulated within mammalian cells. In this article, we first discuss recent findings regarding the regulation of SR protein expression, activity and accessibility. We dive into recent studies describing SR protein auto-regulatory feedback loops involving different molecular mechanisms such asunproductive splicing, microRNA-mediated regulation and translational repression. In addition, we take into account another step of regulation of SR proteins, presenting new findings about a variety of post-translational modifications by proteomics approaches and how some of these modifications can regulate SR protein sub-cellular localization or stability. Towards the end, we focus in two recently revealed functions of SR proteins beyond mRNA biogenesis and metabolism, the regulation of micro-RNA processing and the regulation of small ubiquitin-like modifier (SUMO) conjugation. (c) 2012 IUBMB IUBMB Life, 64(10): 809816, 2012
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