4.5 Review

Regulating the regulators: Serine/arginine-rich proteins under scrutiny

期刊

IUBMB LIFE
卷 64, 期 10, 页码 809-816

出版社

WILEY-BLACKWELL
DOI: 10.1002/iub.1075

关键词

alternative splicing; eukaryotic gene expression; pre-mRNA processing; protein function; protein expression

资金

  1. Agencia Nacional de Promocion Cientifica y Tecnologica of Argentina (ANPCyT)
  2. University of Buenos Aires, Argentina (UBACyT)
  3. European Alternative Splicing Network (EURASNET)
  4. Consejo Nacional de Investigaciones Cientificas y Tecnicas of Argentina (CONICET)

向作者/读者索取更多资源

Serine/arginine-rich (SR) proteins are among the most studied splicing regulators. They constitute a family of evolutionarily conserved proteins that, apart from their initially identified and deeply studied role in splicing regulation, have been implicated in genome stability, chromatin binding, transcription elongation, mRNA stability, mRNA export and mRNA translation. Remarkably, this list of SR protein activities seems far from complete, as unexpected functions keep being unraveled. An intriguing aspect that awaits further investigation is how the multiple tasks of SR proteins are concertedly regulated within mammalian cells. In this article, we first discuss recent findings regarding the regulation of SR protein expression, activity and accessibility. We dive into recent studies describing SR protein auto-regulatory feedback loops involving different molecular mechanisms such asunproductive splicing, microRNA-mediated regulation and translational repression. In addition, we take into account another step of regulation of SR proteins, presenting new findings about a variety of post-translational modifications by proteomics approaches and how some of these modifications can regulate SR protein sub-cellular localization or stability. Towards the end, we focus in two recently revealed functions of SR proteins beyond mRNA biogenesis and metabolism, the regulation of micro-RNA processing and the regulation of small ubiquitin-like modifier (SUMO) conjugation. (c) 2012 IUBMB IUBMB Life, 64(10): 809816, 2012

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据