期刊
IUBMB LIFE
卷 63, 期 12, 页码 1068-1074出版社
WILEY-BLACKWELL
DOI: 10.1002/iub.531
关键词
clonal complexes; comparative genomics; core genome; pan genome; singletons; virulence
资金
- Portuguese Fundacao para a Ciencia e a Tecnologia (FCT) [SFRH/BD/43420/2008]
- German Federal Ministry of Education and Research [0315599B]
- Italian Minister of Health
- Fundação para a Ciência e a Tecnologia [SFRH/BD/43420/2008] Funding Source: FCT
The genome sequences of a number of Acinetobacter baumanii strains, including representatives of the main epidemic international lineages, have now been determined, and several others are in progress. The study of A. baumannii genomics has provided an expanded view of the adaptation and virulence capacities of this bacterial species, whilst also presenting novel insights into its intraspecies diversity and genome evolution. Genomic analyses have revealed that the current A. baumannii clinical population consists of low-grade pathogens, whose pathogenicity relies mainly on an ability to persist in the hospital setting and survive antibiotic treatment. A. baumannii has a high capacity to acquire new genetic determinants and displays an open pan genome; this feature may have played a crucial role in the evolution of this human opportunistic pathogen towards clinical success. (C) 2011 IUBMB IUBMB Life, 63(12): 1068-1074, 2011
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