期刊
IUBMB LIFE
卷 61, 期 7, 页码 731-738出版社
WILEY-BLACKWELL
DOI: 10.1002/iub.200
关键词
integrin; signalling; trafficking; endocytosis; focal adhesion; migration
资金
- Wellcome Trust [074941]
- BBSRC CASE PhD
- GlaxoSmithKline
The formation, maturation, and dissolution of focal adhesions are basic prerequisites of cell migration and rely on the recruitment, signalling, and endocytosis of integrins. In many instances, extracellular matrix molecules are recognised by a number of integrins, and it is the sequential involvement of different integrins that allows establishment of cell polarity and migration towards a matrix stimulus. In this review, we consider both the similarities and differences between two key fibronectin receptors, alpha(V)beta(3) and alpha(5)beta(1) integrin. By considering the GTPase and kinase signalling and trafficking of two such closely-related receptors, we begin to understand how cell migration is coordinated. (C) 2009 IUBMB IUBMB Life, 61(7): 731-738, 2009
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据