期刊
MOLECULAR THERAPY
卷 23, 期 7, 页码 1182-1188出版社
CELL PRESS
DOI: 10.1038/mt.2015.63
关键词
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资金
- Ministry of Education, Science and Culture, Japan
- Ministry of Health and Welfare, Japan
- National Cancer Institute [CA132971, CA142669]
- Grants-in-Aid for Scientific Research [25293283] Funding Source: KAKEN
Fluorescence-guided surgery (FGS) of cancer is an area of intense current interest. However, although benefits have been demonstrated with FGS, curative strategies need to be developed. Glioblastoma multiforme (GBM) is one of the most invasive of cancers and is not totally resectable using standard bright-light surgery (BLS) or current FGS strategies. We report here a curative strategy for FGS of GBM. In this study, telomerase-dependent adenovirus OBP-401 infection brightly and selectively labeled GBM with green fluorescent protein (GFP) for FGS in orthotopic nude mouse models. OBP-401-based FGS enabled curative resection of GBM without recurrence for at least 150 days, compared to less than 30 days with BLS.
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