期刊
IUBMB LIFE
卷 61, 期 12, 页码 1118-1122出版社
JOHN WILEY & SONS INC
DOI: 10.1002/iub.263
关键词
serum heme-albumin; heme binding; serum heme-albumin reactivity; allosteric modulation
资金
- Ministry for Health of Italy
Heme scavenging by plasma proteins, including serum albumin (SA), provides protection against free-heme oxidative damage, limits access by pathogens to the heme, and contributes to iron homeostasis by recycling the heme iron. In turn, serum heme-albumin (SA-heme) acquires heme-based ligand-binding and (pseudo-)enzymatic properties. Heme binding to SA and SA-heme reactivity are allosterically and competitively modulated by endogenous and exogenous third components, this being relevant in pharmacotherapy management. (C) 2009 IUBMB IUBMB Life, 61: 1118-1122, 2009
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