期刊
IUBMB LIFE
卷 62, 期 1, 页码 1-13出版社
WILEY
DOI: 10.1002/iub.281
关键词
galectins; signaling pathways; differentiation; apoptosis; oncogenesis; immune regulation
资金
- The Prostate Cancer Research Foundation
- Association pour la Recherche contre le Cancer de Prostate-ARTP
- Cancer Research Institute
- Fundacion Sales
- Agencia Nacional de Promocion Cientifica y Tecnologica [PICT 2006-603]
- Universidad de Buenos Aires
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
- ANPCyT
Galectins are a family of evolutionarily conserved animal lectins with pleiotropic functions and widespread distribution. Fifteen members have been identified in a wide variety of cells and tissues. Through recognition of cell surface glycoproteins and glycolipids, these endogenous lectins can trigger a cascade of intracellular signaling pathways capable of modulating cell differentiation, proliferation, survival, and migration. These cellular events are critical in a variety of biological processes including embryogenesis, angiogenesis, neurogenesis, and immunity and are substantially altered during tumorigenesis, neurodegeneration, and inflammation. In addition, galectins can modulate intracellular functions and this effect involves direct interactions with distinct signaling pathways. In this review, we discuss current knowledge on the intracellular signaling pathways triggered by this multifunctional family of beta-galactoside-binding proteins in selected physiological and pathological settings. Understanding the galectin signalosome will be essential to delineate rational therapeutic strategies based on the specific control of galectin expression and function. (C) 2009 IUBMB IUBMB Life, 62(1): 1-13, 2010
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