期刊
IUBMB LIFE
卷 60, 期 12, 页码 824-833出版社
WILEY
DOI: 10.1002/iub.129
关键词
beta-globin; locus control region; active chromatin hub; chromatin looping; nuclear organization
资金
- Dutch Scientific Organization (NWO) [016-006-026, 912-04-082]
The mammalian beta-globin locus is a multigene locus containing several globin genes and a number of regulatory elements. During development, the expression of the genes changes in a process called switching. The most important regulatory element in the locus is the locus control region (LCR) upstream of the globin genes that is essential for high-level expression of these genes. The discovery of the LCR initially raised the question how this element could exert its effect on the downstream globin genes. The question was solved by the finding that the LCR and activate globin genes are in physical contact, forming a chromatin structure named the active chromatin hub (ACH). Here we discuss the significance of ACH formation, provide an overview of the proteins implicated in chromatin looping at the beta-globin locus, and evaluate the relationship between nuclear organization and beta-globin gene expression. (C) 2008 IUBMB
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