期刊
ISRAEL JOURNAL OF CHEMISTRY
卷 51, 期 3-4, 页码 453-472出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ijch.201100020
关键词
AIDS; Alzheimer's disease; bryostatin; function-oriented synthesis; protein kinase C (PKC)
资金
- NCI NIH HHS [R37 CA031845, R37 CA031845-32] Funding Source: Medline
We review in part our computational, design, synthesis, and biological studies on a remarkable class of compounds and their designed analogs that have led to preclinical candidates for the treatment of cancer, a first-in-class approach to Alzheimer's disease, and a promising strategy to eradicate HIV/AIDS. Because these leads target, in part, protein kinase C (PKC) isozymes, they have therapeutic potential even beyond this striking set of therapeutic indications. This program has given rise to new synthetic methodology and represents an increasingly important direction of synthesis focused on achieving function through synthesis-informed design (function-oriented synthesis).
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