Vinyl Dibromides: Versatile Partners in Cross-Coupling Reactions

Once limited to the preparation of alkynes, the chemistry of 1,1-dibromoalkenes has clearly undergone a renaissance through the application of palladium and copper catalysis. Remarkably efficient, innovative, and reliable methods have been recently designed around this chemistry, which has found many applications for the preparation of sophisticated building blocks as well as natural and/or biologically active products. This review article highlights major developments in this area.