期刊
ISRAEL JOURNAL OF CHEMISTRY
卷 50, 期 2, 页码 220-232出版社
SCIENCE FROM ISRAEL-DIVISION OF LASER PAGES PUBL LTD
DOI: 10.1002/ijch.201000016
关键词
polydisulfide; biodegradable macromolecular contrast agents; copolymerization; gadolinium; degradation
资金
- NIH [R01 EB00489]
- NATIONAL CANCER INSTITUTE [R21CA095873, R01CA097465, R41CA128130, R41CA135785, R33CA095873] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB000489] Funding Source: NIH RePORTER
Macromolecular Gd(III) complexes are advantageous over small molecular Gd(III) complexes in contrast-enhanced magnetic resonance imaging (MRI) because of their prolonged blood circulation and preferential tumor accumulation. However, macromolecular contrast agents have not been approved for clinical applications because of the safety concerns related to their slow body excretion. Polydisulfide Gd(III) complexes have been designed and developed as biodegradable macromolecular MRI contrast agents to alleviate these concerns by facilitating the clearance of Gd(III) complexes from the body. These agents initially behave as macromolecular agents and result in superior contrast enhancement in the vasculature and tumor tissues. They can then be readily degraded in vivo into small molecular chelates that can be rapidly excretede from the body via renal filtration after the MRI examinations. Various polydisulfide Gd(III) complexes have been prepared as biodegradable macromolecular MRI contrast agents. These agents have resulted in strong contrast enhancement in the vasculature and tumor tissue in animal models with minimal long-term tissue accumulation when compared to small molecular contrast agents. Polydisulfide Gd(III) complexes are promising for further clinical development as safe and effective biodegradable macromolecular MRI contrast agents for cardiovascular and cancer imaging. The review summarizes the chemistry and properties of polydisulfide Gd(III) complexes.
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