期刊
ISME Journal
卷 9, 期 5, 页码 1260-1263出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ismej.2014.187
关键词
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资金
- Ministerio de Ciencia e Innovacion (MICINN, Spain) [Consolider-Ingenio CSD2009-00006, BIO2011-30503-C02-01, Eranetpathogenomics PIM2010EPA-00606]
- National Institutes of Health [R01AI022159]
Bacteriophage-mediated horizontal gene transfer is one of the primary driving forces of bacterial evolution. The pac-type phages are generally thought to facilitate most of the phage-mediated gene transfer between closely related bacteria, including that of mobile genetic elements-encoded virulence genes. In this study, we report that staphylococcal cos-type phages transferred the Staphylococcus aureus pathogenicity island SaPIbov5 to non-aureus staphylococcal species and also to different genera. Our results describe the first intra-and intergeneric transfer of a pathogenicity island by a cos phage, and highlight a gene transfer mechanism that may have important implications for pathogen evolution.
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