期刊
ISME JOURNAL
卷 6, 期 8, 页码 1578-1585出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ismej.2012.5
关键词
Faecalibacterium prausnitzii; extracellular electron transfer; exogenous electron mediator; riboflavin; thiols; gut-health
资金
- Graduate School GUIDE of the University of Groningen
- Scottish Government Rural and Environment Research and Analysis Directorate
- Chemical Sciences division of the Netherlands Organization for Scientific Research (NWO)
Faecalibacterium prausnitzii is one of the most abundant bacteria in the human gut ecosystem and it is an important supplier of butyrate to the colonic epithelium. Low numbers of faecalibacteria have been associated with inflammatory bowel disease. Despite being extremely oxygen sensitive, F. prausnitzii is found adherent to the gut mucosa where oxygen diffuses from epithelial cells. This paradox is now explained on the basis of gas tube experiments, flavin-dependent reduction of 5,5'-dithiobis-2-nitrobenzoate and microbial fuel cell experiments. The results show that F. prausnitzii employs an extracellular electron shuttle of flavins and thiols to transfer electrons to oxygen. Both compounds are present in the healthy human gut. Our observations may have important implications for the treatment of patients with Crohn's disease, for example, with flavin-or antioxidant rich diets, and they provide a novel key insight in host-microbe interactions at the gut barrier. The ISME Journal (2012) 6, 1578-1585; doi:10.1038/ismej.2012.5; published online 23 February 2012
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据