期刊
ISME JOURNAL
卷 5, 期 3, 页码 519-531出版社
SPRINGERNATURE
DOI: 10.1038/ismej.2010.129
关键词
core microbiota; 16S rRNA gene; human; evolution
资金
- Foundation for Research Levy on Agricultural Products
The potential presence of widespread and stable bacterial core phylogroups in the human colon has promoted considerable attention. Despite major efforts, no such phylogroups have yet been identified. Therefore, using a novel phylogroup- and tree-independent approach, we present a reanalysis of 1 114 722 V2 region and 71 550 near full-length 16S rRNA sequences from a total of 210 human beings, with widespread geographic origin, ethnic background and diet, in addition to a wide range of other mammals. We found two highly prevalent core phylogroups (cores 1 and 2), belonging to the clostridial family Lachnospiraceae. These core phylogroups showed a log-normal distribution among human individuals, while non-core phylogroups showed more skewed distributions towards individuals with low levels compared with the log-normal distribution. Molecular clock analyses suggest that core 2 co-evolved with the radiation of vertebrates, while core 1 co-evolved with the mammals. Taken together, the stability, prevalence and potential functionality support the fact that the identified core phylogroups are pivotal in maintaining gut homeostasis and health. The ISME Journal (2011) 5, 519-531; doi: 10.1038/ismej.2010.129; published online 26 August 2010
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