期刊
MOLECULAR REPRODUCTION AND DEVELOPMENT
卷 82, 期 3, 页码 151-166出版社
WILEY-BLACKWELL
DOI: 10.1002/mrd.22462
关键词
-
资金
- American Heart Association [12GRNT12060070]
- National Institutions of Health (NIDDK)
The mammalian metanephric kidney is composed of two epithelial components, the collecting duct system and the nephron epithelium, that differentiate from two different tissues the ureteric bud epithelium and the nephron progenitors, respectivelyof intermediate mesoderm origin. The collecting duct system is generated through reiterative ureteric bud branching morphogenesis, whereas the nephron epithelium is formed in a process termed nephrogenesis, which is initiated with the mesenchymal-epithelial transition of the nephron progenitors. Ureteric bud branching morphogenesis is regulated by nephron progenitors, and in return, the ureteric bud epithelium regulates nephrogenesis. The metanephric kidney is physiologically divided along the corticomedullary axis into subcompartments that are enriched with specific segments of these two epithelial structures. Here, we provide an overview of the major molecular and cellular processes underlying the morphogenesis and patterning of the ureteric bud epithelium and its roles in the cortico-medullary patterning of the metanephric kidney. Mol. Reprod. Dev. 82: 151-166, 2015. (c) 2015 Wiley Periodicals, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据