期刊
MOLECULAR PSYCHIATRY
卷 20, 期 6, 页码 677-684出版社
SPRINGERNATURE
DOI: 10.1038/mp.2015.30
关键词
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资金
- National Institute of Mental Health [R01MH100616]
- Brain and Behavior Young Investigator Grant
- National Institute of Health (NIH) [R01 MH101454, R01 MH106056]
- New York Stem Cell Foundation
The human genome project has revolutionized our understanding of the underlying mechanisms in psychiatric disease. It is now abundantly clear that neurobehavioral phenotypes are epigenetically controlled by noncoding RNAs (ncRNAs). The microRNA (miRNA) class of ncRNAs are ubiquitously expressed throughout the brain and govern all major neuronal pathways. The attractive therapeutic potential of miRNAs is underscored by their pleiotropic capacities, putatively targeting multiple pathways within a single neuron. Many psychiatric diseases stem from a multifactorial origin, thus conventional drug targeting of single proteins may not prove most effective. In this exciting post-genome sequencing era, many new epigenetic targets are emerging for therapeutic investigation. Here we review the reported roles of miRNAs, as well as other ncRNA classes, in the pathology of psychiatric disorders; there are both common and unique ncRNA mechanisms that influence the various diagnoses. Collectively, these potent epigenetic regulators may clarify the disrupted signaling networks in psychiatric phenotypes.
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