期刊
MOLECULAR PSYCHIATRY
卷 21, 期 3, 页码 364-375出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/mp.2015.18
关键词
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资金
- ZonMw Vidi from Netherlands Organization for Scientific Research, NeuroBasic-PharmaPhenomics consortium, Dutch Technology Foundation STW [017.106.384]
- Ministry of Economic Affairs [12197]
- FP7 EU Marie Curie [254711]
- Fundacao para a Ciencia e Tecnologia
Memories are encoded within sparsely distributed neuronal ensembles. However, the defining cellular properties of neurons within a memory trace remain incompletely understood Using a fluorescence-based Arc reporter, we were able to visually identify the distinct subset of lateral amygdala (LA) neurons activated during auditory fear conditioning. kAte found that Arc-expressing neurons have enhanced intrinsic excitability and are preferentially recruited into newly encoded memory traces. Furthermore, synaptic potentiation of thalamic inputs to the LA during fear conditioning is learning-specific, postsynaptically mediated and highly localized to Arc-expressing neurons. Taken together, our findings validate the immediate-early gene Arc as a molecular marker for the LA neuronal ensemble recruited during fear learning. Moreover, these results establish a model of fear memory formation in which intrinsic excitability determines neuronal selection, whereas learning-related encoding is governed by synaptic plasticity.
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