Detection of urinary modified nucleosides by a bulk acoustic wave MIP sensor - Results and future work

This paper presents an overview of the main actions and projects of the ANR TECSAN CancerSensor during the 2011-2014 period. The project aims to develop and validate a quantitative, non-invasive therapeutic tool to detect selected urinary modified nucleosides as biomarkers of colorectal cancer chemotherapy and to monitor in fine the efficiency of the chemotherapy. A methodology has been developed to generate a bulk acoustic wave molecularly imprinted polymer sensor (SAW-MIP) for the detection of various nucleosides and nucleotides of interest. A rapid and sensitive mass spectrometry method has been also developed. (C) 2014 Elsevier Masson SAS. All rights reserved.