Encapsulation of bovine serum albumin within β-cyclodextrin/gelatin-based polymeric hydrogel for controlled protein drug release

Novel biodegradable pH-responsive polymeric hydrogels based on beta-cyclodextrin (beta-CD) and gelatin (G) were prepared for controlled protein drug delivery studies The polymeric hydrogels. G-g-poly(GMA) were obtained by grafting copolymerization of glycidyl methacrylate monomer (GMA) onto gelatin in presence of ammonium eerie nitrate (CAN) as initiator Immobilization of beta-CD onto G-g-poly(GMA) hydrogel was then carried out The prepared polymeric hydrogels were characterized by Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), two dimension X-ray diffraction pattern (2D-XRD) and transmitting electron microscope (TEM) A model protein drug. bovine serum albumin (BSA), was encapsulated in these hydrogels and the in yam release profiles were established separately in both enzyme-free simulated gastric and intestinal fluids (SGF and SIF, respectively) (C) 2010 Elsevier Masson SAS All rights reserved