期刊
INVESTIGATIONAL NEW DRUGS
卷 36, 期 6, 页码 1116-1132出版社
SPRINGER
DOI: 10.1007/s10637-018-0624-7
关键词
Osteosarcoma; microRNAs; Long non-coding RNAs; circRNAs
资金
- National Natural Science Foundation of China [81702656]
- Natural Science Foundation of Anhui Province [1708085QH215]
Non-coding RNAs (ncRNAs) have been found to play essential roles in various physiological and pathological processes. The involvement of ncRNAs in the development of osteosarcoma (OS) has been explored in recent years. In this review, we summarize the functions and mechanisms of microRNA, lncRNA and circRNA in the initiation and progression of OS. We specifically focused on their potential application in the diagnosis, prognosis and therapy of OS. This summary of current knowledge on the involvement of ncRNAs in OS will not only aid comprehension of the complex processes of OS initiation and progression but also contribute to the exploration of ideal diagnostic biomarkers and therapeutic targets for OS patients.
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