期刊
MOLECULAR PLANT
卷 8, 期 6, 页码 860-870出版社
CELL PRESS
DOI: 10.1016/j.molp.2015.01.021
关键词
epigenomics; DNA methylation; whole-genome bisulfite sequencing (WGBS); crops; comparative genomics
资金
- National Science Foundation [IOS-1339194]
- National Institutes of Health [R00GM100000]
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [1339194] Funding Source: National Science Foundation
DNA methylation is a key chromatin modification in plant genomes that is meiotically and mitotically heritable, and at times is associated with gene expression and morphological variation. Benefiting from the increased availability of high-quality reference genome assemblies and methods to profile single-base resolution DNA methylation states, DNA methylomes for many crop species are available. These efforts are making it possible to begin answering crucial questions, including understanding the role of DNA methylation in developmental processes, its role in crop species evolution, and whether DNA methylation is dynamically altered and heritable in response to changes in the environment. These genome-wide maps provide evidence for the existence of silent epialleles in plant genomes which, once identified, can be targeted for reactivation leading to phenotypic variation.
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