期刊
INVERTEBRATE REPRODUCTION & DEVELOPMENT
卷 59, 期 -, 页码 39-44出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/07924259.2014.938196
关键词
Hydra; FoxO; senescence; stem cells; piRNAs; longevity
资金
- National Institute on Aging [1R01AG037965-01]
Hydra represents a unique model system for the study of senescence, with the opportunity for the comparison of non-aging and induced senescence. Hydra maintains three stem cell lineages, used for continuous tissue morphogenesis and replacement. Recent work has elucidated the roles of the insulin/IGF-1 signaling target FoxO, of Myc proteins, and of PIWI proteins in Hydra stem cells. Under laboratory culture conditions, Hydra vulgaris show no signs of aging even under long-term study. In contrast, Hydra oligactis can be experimentally induced to undergo reproduction-associated senescence. This provides a powerful comparative system for future studies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据