期刊
INTERNATIONAL UROLOGY AND NEPHROLOGY
卷 51, 期 1, 页码 93-100出版社
SPRINGER
DOI: 10.1007/s11255-018-1951-5
关键词
ADPKD; Cancer; Association
资金
- National Natural Science Foundation of China [81700579, 81670612]
- Three-year Project of Action for Shanghai Public Health System [GWIV-18]
- National Key Research and Development Program of China [2016YFC0901502]
Autosomal dominant polycystic kidney disease (ADPKD) is considered as a tumor-like disease because there are many biological similarities between ADPKD and cancer. However, the commonalities between them are provocative, particularly under the conditions of recent clinical studies. In this paper, we review clinical studies about the association between cancer and ADPKD, and compare the biological characteristics between them, with focusing on cell proliferation, differentiation, migration, apoptosis, and polarity. With detailed literature reviewing, we believe that ADPKD patients have a higher risk of tumorigenesis and thus highly recommend being aware of tumorigenesis during follow-up in patients with ADPKD.
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