期刊
MOLECULAR PHARMACEUTICS
卷 12, 期 9, 页码 3250-3260出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.molpharmaceut.5b00216
关键词
gold nanoparticles; epidermal growth factor; transferrin; Pc 4; glioblastoma
资金
- National Institute of Biomedical Imaging and Bioengineering (NIBIB) [R01EB012099]
Targeting gold nanoparticles (AuNPs) with two or more receptor binding peptides has been proposed to address intratumoral heterogeneity of glioblastomas that overexpress multiple cell surface receptors to ultimately improve therapeutic efficacy. AuNPs conjugated with peptides against both the epidermal growth factor and transferrin receptors and loaded with the photosensitizer phthalocyanine 4 (Pc 4) have been designed and compared with monotargeted AuNPs for in vitro and in vivo studies. The (EGF(pep)+Tf-pep)-AuNPs-Pc 4 with a particle size of similar to 41 nm improved both specificity and worked synergistically to decrease time of maximal accumulation in human glioma cells that overexpressed two cell surface receptors as compared to cells that overexpressed only one. Enhanced cellular association and increased cytotoxicity were achieved. In vivo studies show notable accumulation of these agents in the brain tumor regions.
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