期刊
MOLECULAR PHARMACEUTICS
卷 12, 期 2, 页码 420-431出版社
AMER CHEMICAL SOC
DOI: 10.1021/mp500527x
关键词
amphotericin B; oral delivery; N-palmitoyl,N-methyl-N,N-dimethyl-N,N,N-trimethyl-6-O-glycol chitosan; nanoparticles; nanomedicine
资金
- UCL School of Pharmacy, Complutense University
- Madrid Community Administration [910939]
- Spanish Ministry of Education [AP2008-00235]
- EU [601963]
- EPSRC [EP/L024748/1, EP/L024772/1, EP/K502340/1, EP/K502339/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/K502340/1, EP/L024748/1, EP/L024772/1, EP/K502339/1] Funding Source: researchfish
There are very few drug delivery systems that target key organs via the oral route, as oral delivery advances normally address gastrointestinal drug dissolution, permeation, and stability. Here we introduce a nanomedicine in which nanoparticles, while also protecting the drug from gastric degradation, are taken up by the gastrointestinal epithelia and transported to the lung, liver, and spleen, thus selectively enhancing drug bioavailability in these target organs and diminishing kidney exposure (relevant to nephrotoxic drugs). Our work demonstrates, for the first time, that oral particle uptake and translocation to specific organs may be used to achieve a beneficial therapeutic response. We have illustrated this using amphotericin B, a nephrotoxic drug encapsulated within N-palmitoyl-N-methyl-N,N-dimethyl-N,N,N-trimethyl-6-O-glycol chitosan (GCPQ) nanoparticles, and have evidenced our approach in three separate disease states (visceral leishmaniasis, candidiasis, and aspergillosis) using industry standard models of the disease in small animals. The oral bioavailability of AmB-GCPQ nanoparticles is 24%. In all disease models, AmB-GCPQ nanoparticles show comparable efficacy to parenteral liposomal AmB (AmBisome). Our work thus paves the way for others to use nanoparticles to achieve a specific targeted delivery of drug to key organs via the oral route. This is especially important for drugs with a narrow therapeutic index.
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