期刊
INTERNATIONAL REVIEWS OF IMMUNOLOGY
卷 31, 期 2, 页码 104-118出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/08830185.2012.668982
关键词
B cells; inflammation; integrin; neutrophils; Tec-kinase
类别
资金
- German Research Foundation [AZ 428/3-1, AZ 428/6-1]
- Interdisciplinary Clinical Research Center (IZKF Muenster, Germany) [Za2/001/10]
Recruitment of leukocytes into inflamed tissue is a key component of the immune system. The activation of integrins on leukocytes is required for their recruitment into the inflamed tissue. Btk is a cytoplasmic nonreceptor tyrosine kinase belonging to the Tec-kinase family. It plays a key role in B-cell development and function, and recently published studies revealed important roles of Btk inmyeloid cells. Btk might be activated through a variety of receptors leading to activation of integrins as the pivotal element in leukocyte recruitment. This review focuses on the role of Btk in B-lymphocyte homing and in neutrophil recruitment.
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