期刊
INTERNATIONAL REVIEWS OF IMMUNOLOGY
卷 29, 期 2, 页码 133-155出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/08830180903349669
关键词
dendritic cells; indoleamine 2,3 dioxygenase; T cells; regulation
类别
资金
- Scientific Board of NewLink Genetics Inc.
Dendritic cells (DCs) are specialized to stimulate T cell immunity. Paradoxically, some DCs suppress T cell responses and activate regulatory T cells. In this review, we focus on a potent counter-regulatory pathway mediated by plasmacytoid DCs (pDCs) expressing the immunosuppressive enzyme indoleamine 2,3 dioxygenase (IDO). IDO-expressing pDCs inhibit effector T cell responses, activate regulatory T cells, and attenuate pro-inflammatory responses in settings of chronic inflammation that manifest in clinical syndromes, such as infectious, allergic, and autoimmune diseases; cancer; and transplantation. Thus, IDO-expressing pDCs create immune privilege and provide novel opportunities to improve immunotherapy in multiple disease syndromes.
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