期刊
INTERNATIONAL REVIEWS OF IMMUNOLOGY
卷 28, 期 6, 页码 506-534出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/08830180903197480
关键词
arachidonic acid; eicosapentaenoic acid; docosahexaenoic acid; fish oil; inflammation; eicosanoid; cytokine; macrophage; lymphocyte
类别
Fatty acids may influence immune function through a variety of mechanisms; many of these are associated with changes in fatty acid composition of immune cell membranes. Eicosanoids produced from arachidonic acid have roles in inflammation and immunity. Increased membrane content of n-3 fatty acids results in a changed pattern of production of eicosanoids, resolvins, and cytokines. Changing the fatty acid composition of immune cells also affects T cell reactivity and antigen presentation. Little attention has been paid to the influence of fatty acids on the gutassociated lymphoid tissue. However, there has been considerable interest in fatty acids and gut inflammation.
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