期刊
MOLECULAR ONCOLOGY
卷 10, 期 3, 页码 395-407出版社
WILEY
DOI: 10.1016/j.molonc.2015.12.002
关键词
Circulating tumor cells; CellSearch; Rare event detection; Epithelial cell adhesion molecule
类别
资金
- European Commission (EU) [305341, 115749]
- Janssen Diagnostics
Enumeration and characterization of circulating tumor cells (CTC) hold the promise of a real time liquid biopsy. They are however present in a large background of hematopoietic cells making their isolation technically challenging. In 2004, the CellSearch system was introduced as the first and only FDA cleared method designed for the enumeration of circulating tumor cells in 7.5 mL of blood. Presence of CTC detected by CellSearch is associated with poor prognosis in metastatic carcinomas. CTC remaining in patients after the first cycles of therapy indicates a futile therapy. Here we review challenges faced during the development of the CellSearch system and the difficulties in assigning objects as CTC. The large heterogeneity of CTC and the different approaches introduced in recent years to isolate, enumerate and characterize CTC results in a large variation of the number of CTC reported urging the need for uniform definitions and at least a clear definition of what the criteria are for assigning an object as a CTC. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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