期刊
MOLECULAR NUTRITION & FOOD RESEARCH
卷 59, 期 11, 页码 2326-2336出版社
WILEY
DOI: 10.1002/mnfr.201500290
关键词
Endothelial dysfunction; Gut microbiota; Hypertension; Probiotic bacteria; SHR
资金
- Comision Interministerial de Ciencia y Tecnologia [SAF2014-55523-R, SAF2010-22066-C02-01, SAF2010-22066-C02-02]
- Junta de Andalucia (Proyecto de excelencia) [P12-CTS-2722, AGR-6826, CTS 164]
- European Union
- Ministerio de Ciencia e Innovacion, Instituto de Salud Carlos III (RIC, CIBER-ehd), Spain [RD12/0042/0011]
Scope: The cardiovascular effects of probiotics Lactobacillus fermentum CECT5716 (LC40), or L. coryniformis CECT5711 (K8) plus L. gasseri CECT5714 (LC9) (1: 1) in spontaneously hypertensive rats (SHR) were evaluated. Methods and results: Ten Wistar Kyoto rats (WKY) and 30 SHR were randomly assigned to four groups (n = 10): a control WKY group, a control SHR groups, an SHR group treated with LC40, and an SHR treated with K8/LC9 group for 5 weeks (at a dose of 3.3 x 10(10) colony-forming units/day in drinking water). Long-term administration of probiotics reduced systolic blood pressure. The consumption of K8/LC9 mixture significantly reduced the cardiac and renal hypertrophy. Both groups of probiotics reversed the impaired aortic endothelium-dependent relaxation to acetylcholine observed in SHR. They also abolished the increased aortic superoxide levels by reducing the increased toll-like receptor-4 mRNA levels and NADPH oxidase activity found in SHR. K8/LC9 consumption also increased endothelial nitric oxide synthase phosphorylation. Probiotic treatments induced a change in the cecum microbiota of SHR, with higher counts of the Lactobacillus spp. cluster, and lower counts of Bacteriodes spp. and Clostridium spp. Conclusion: Probiotics exert cardiovascular protective effects in genetic hypertension related to the improvement of vascular pro-oxidative and pro-inflammatory status.
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