期刊
MOLECULAR NUTRITION & FOOD RESEARCH
卷 59, 期 10, 页码 1987-1996出版社
WILEY
DOI: 10.1002/mnfr.201500336
关键词
HDL; Oxidation; Reverse cholesterol transport; Saturated fatty acids; Polyunsaturated fatty acids
资金
- European Cooperation in Science and Technology (COST) action [BM0904]
- Ministerio de Sanidad y Consumo
- Instituto de Salud Carlos III [FIS 12-00291, PI13-00364]
- Fondos FEDER
- Academy of Finland [257545]
- Miguel Servet Type 1 contract [CP13-00070]
Scope: The present study aimed to compare the effects of diets containing high-fat, high-cholesterol and saturated fatty acids (HFHC-SFA) and HFHC-polyunsaturated fatty acids-containing (HFHC-PUFA) diets on two major antiatherogenic functions of HDL, the HDL antioxidant function and the macrophage-to-feces reverse cholesterol transport. Methods and results: Experiments were carried out in mice fed a low-fat, low-cholesterol (LFLC) diet, an HFHC-SFA diet or an HFHC-PUFA diet in which SFAs were partly replaced with an alternative high-linoleic and alpha-linolenic fat source. The HFHC-SFA caused a significant increase in serum HDL cholesterol and phospholipids as well as elevated levels of oxidized HDL and oxidized LDL. Replacing SFA with PUFA significantly reduced the levels of these oxidized lipoproteins and enhanced the ability of HDL to protect LDL from oxidation. The SFA-mediated impairment of HDL antioxidant potential was not associated with the cholesterol content of the diet, obesity or insulin resistance. In contrast, the effect of the HFHC diets on fecal macrophage-derived cholesterol excretion was independent of the fatty acid source. Conclusion: SFA intake impairs the antioxidant potential of HDL and increases serum levels of oxidized lipoprotein species whereas the antioxidant potential of HDL is enhanced after PUFA consumption.
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