Serum Levels of Brain-Derived Neurotrophic Factor Are Associated with Diabetes Risk, Complications, and Obesity: a Cohort Study from Chinese Patients with Type 2 Diabetes

Brain-derived neurotrophic factor (BDNF) is associated with systemic inflammatory conditions, such as diabetes. The aim of this study was to assess the serum BDNF levels in Chinese patients with type 2 diabetes (T2DM). From the outpatient clinic at the endocrinology department of our hospital, all patients with long-standing T2DM were recruited for this study between August 2014 and December 2014. Serum levels of BDNF were assayed with solid-phase sandwich ELISA, and the demographical and clinical data were evaluated on admission. Median serum BDNF levels were significantly lower in patients with T2DM compared to control subjects (15.9 ng/mL (interquartile range (IQR), 12.6-19.8) VS. 24.6 ng/mL (IQR, 17.2-27.8); P < 0.0001). Serum BDNF levels were inversely correlated with fasting glucose (r = -0.394, P < 0.0001) and duration of illness (r = -0.272, P < 0.0001) in T2DM patients. Based on the receiver operating characteristic (ROC) curve, the optimal cutoff value of serum BDNF levels as an indicator for diagnosis of T2DM was projected to be 23.0 ng/mL, which yielded a sensitivity of 89.0 % and a specificity of 60.9 %, with the area under the curve at 0.794 (95 % confidence interval (CI), 0.747-0.841; P < 0.001). In multivariate logistic regression analysis, after adjusting for other significant factors, BDNF can be seen as an indicator of independent diabetes complications with an odds ratio (OR) of 0.84 (95 % CI, 0.75-0.89; P < 0.001) and obesity with an OR of 0.88 (95 % CI, 0.80-0.92; P < 0.001). Our study suggested that low levels of BDNF accompany impaired glucose metabolism. Importantly, we found that decreased BDNF were correlated with obesity and diabetes complications.