期刊
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
卷 16, 期 11, 页码 1510-1516出版社
INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)
DOI: 10.5588/ijtld.12.0049
关键词
retreatment tuberculosis; re-infection; HIV; antiretroviral therapy; molecular epidemiology
资金
- National Institutes of Health (NIH) Comprehensive Integrated Programme of Research on AIDS (CIPRA) [1U19AI053217]
- NIH CIPRA [1U19AI05321]
- NIH [AI058736-02, AI66046, AI 080737]
- Wellcome Trust Strategic Award: Clinical Infectious Diseases Research Initiative [WT084323MA]
BACKGROUND: Limited data exist on the impact of human immunodeficiency virus (HIV) or antiretroviral treatment (ART) on retreatment tuberculosis (TB). METHODS: Retreatment TB episodes between 2001 and 2010 in a high HIV and TB burden community were linked to first-episode treatment outcomes, HIV status and ART use. Genotypic analysis of Mycobacterium tuberculosis isolates distinguished re-infection from reactivation TB. RESULTS: A total of 2027 TB episodes occurred in 1755 adults: 564 were retreatment cases. New patients who interrupted or failed initial treatment, were HIV-positive or were not on ART more frequently developed retreatment TB (respectively P < 0.001, P = 0.01 and P = 0.02). Time intervals between successive diagnoses were shorter in patients who interrupted/failed treatment compared to those with favourable initial treatment outcomes (P < 0.001), but did not vary by HIV status or ART use. Genotypic data were available for 40 successive diagnoses, of which 19 had matching M. tuberculosis strains. Matching strains were associated with HIV-negative status (P < 0.001), treatment interruption/failure (P = 0.04) and shorter intervals between diagnoses (P = 0.02). HIV-positive patients and patients on ART were more likely to have non-matched strains (P = 0.01 and P = 0.03). CONCLUSION: Among HIV-negative patients, retreatment TB was predominantly due to reactivation following poor initial treatment outcomes. In HIV-positive patients re-infection TB was more common, particularly among those on ART.
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