期刊
INTERNATIONAL JOURNAL OF TOXICOLOGY
卷 33, 期 2, 页码 98-105出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1091581814523142
关键词
anticancer compounds; cardiovascular toxicity; acute toxicity; developmental toxicity; zebrafish
资金
- Jiangsu Provincial Natural Science Fund [BK2011796]
- New Teacher Fund from Chinese Ministry of Education [20123221120005]
- National Natural Science Foundation of China [81172947, 81073129]
Toxicity is one of the major reasons for failure in drug development. Zebrafish, as an ideal vertebrate model, could also be used to evaluate drug toxicity. In this study, we aimed to show the predictability and highlight novel findings of toxicity in zebrafish model. Seven anticancer compounds, including triptolide (TP), gambogic acid (GA), mycophenolic acid (MPA), curcumin, auranofin, thalidomide, and taxol, were assessed in zebrafish for their toxicity. Three compounds (GA, TP, and taxol) showed highest acute lethality, with 50% lethal concentration approximate to 1 mu mol/L. Missing tails, severe pericardial edema, and enlarged yolk sacs were observed in MPA-treated embryos. The development of pectoral fins was severely disturbed in thalidomide-, GA-, and TP-treated embryos. Bradycardia was observed in MPA- and thalidomide-treated groups. Our findings suggested that the zebrafish are a good model for toxicity assessment of anticancer compounds.
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