期刊
INTERNATIONAL JOURNAL OF TOXICOLOGY
卷 29, 期 6, 页码 625-633出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1091581810383705
关键词
rosmarinic acid; MPP+; Parkinson's disease; apoptosis
资金
- Natural Science Foundation of Shandong Province [Z2008C01]
Rosmarinic acid (RA) is a naturally occurring polyphenolic compound found in various plant families. We previously reported that RA exerted protective effects against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity through antioxidative properties. In this study, we investigated whether RA could prevent effects of 1-methyl-4-phenylpyridinium (MPP+)-induced insult in MES23.5 dopamineric cells. 1-Methyl-4-phenylpyridinium treatment decreased cell viability and dopamine content, as well as caused apoptotic morphological changes. 1-Methyl-4-phenylpyridinium-induced mitochondrial dysfunction, indicated by inhibition of activity associated with mitochondrial respiratory chain complex 1, suggested mitochondrial transmembrane potential collapse and generation of reactive oxygen species. Decreased Bcl-2/Bax ratio and caspase 3 activation were also observed. Rosmarinic acid pretreatment restored the complex 1 activity of the mitochondrial respiratory chain and partially reversed the other damaging effects of MPP+. Our results indicate that RA plays a neuroprotective role by ameliorating mitochondrial dysfunction against MPP+-induced cell apoptosis and suggest that RA has the potential to be considered an aid for prevention of Parkinson's disease.
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