期刊
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
卷 21, 期 2, 页码 133-141出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1066896912471851
关键词
oral squamous carcinoma; preoperative biopsy; podoplanin; E-cadherin; lymph node metastasis; prognosis
资金
- Regione Emilia Romagna (Italy)
- Italian Ministry for the University and Research (MIUR)
- Vanda Vanini e Sandro Cavagnino grants, from the Centro Interdipartimentale di Ricerche sul Cancro G Prodi, of the University of Bologna
Metastases to cervical lymph nodes (LNs) are an important independent adverse indicator in the prognosis of oral squamous cell carcinoma (OSCC). An accurate evaluation of molecular patterns favoring the metastatic process can be helpful in predicting cases of OSCC with elevated probability of early or late metastases and, moreover, in planning the proper therapeutic procedures before surgery. To this end, immunohistochemical expressions of both E-cadherin and podoplanin were evaluated on preoperative incisional biopsies of OSCC from 102 patients. The probability to have or develop metastases was very low when high E-cadherin expression was found in a preoperative sample or when a low podoplanin expression was found. Therefore, because of the strong association with LN metastases, high E-cadherin/low podoplanin immunohistochemical expression should also be assessed on preoperative incisional biopsies as a useful tool for evaluating the probability of early or late LN metastases of OSCCs.
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