期刊
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
卷 20, 期 6, 页码 629-632出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1066896912441830
关键词
cribriform-morular variant; papillary thyroid carcinoma; immunohistochemistry
The description of the histological features and the immunohistochemical and molecular analyses of a case of cribriform-morular variant of papillary thyroid carcinoma in an 8-year-old girl with a family history of adenomatous polyposis is presented. The neoplasm was multifocal and bilateral, with a mixed pattern of solid, trabecular, and morular areas. The neoplasm showed angioinvasive behavior, extracapsular infiltration with extension to the perythyroidal muscles, and lymph node metastases. Tumor cells were positive for CAM 5.2, cytokeratins 5/6, TTF-1, HBME-1, galectin-3, and beta-catenin. In addition, the molecular tests did not reveal BRAF mutations, RET/PTC rearrangement, APC mutation, or KRAS mutation.
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