期刊
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
卷 19, 期 5, 页码 607-613出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1066896910362080
关键词
breast cancer; Notch receptors; breast prognostic markers; JAG1 Notch ligand; Notch-1; Notch-4
资金
- Cardinal Bernardin Cancer Center, Loyola University Medical Center
- American Cancer Society Illinois Division
Background: Studies looking at immunohistochemical (IHC) staining of Notch receptors in breast cancer and correlation with known prognostic factors are sparse. Methods: IHC staining for nuclear, cytoplasmic, and membrane Notch-1 (N1), Notch-4 (N4), and Jagged-1 (JAG1) was performed and correlated with known prognostic factors. Results: Of 48 breast cancers, 36 (67%) were invasive, mean age was 50 years (range 43-86 years), 37 (77%) were estrogen receptor (ER alpha) positive, and 13 (27%) node positive. There was significantly more marked N1 membranous staining in ER alpha-positive tumors (P < .05). On univariate analysis, cytoplasmic N1 was significantly correlated with node status and tumor grade (P < .05); both cytoplasmic and membranous N4 significantly correlated with Ki67 (P < .05); and membranous JAG1 significantly correlated with Ki67 (P < .05). On multivariate analysis, only cytoplasmic N1 significantly correlated with node status. Conclusion: IHC of Notch markers is feasible and correlates with known prognostic factors consistent with a biological role of Notch signaling in breast cancer progression.
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