期刊
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
卷 19, 期 3, 页码 335-341出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1066896909333511
关键词
breast; angiogenesis; hyperplasia; ductal carcinoma in situ; CD31; CD105; vascular endothelial growth factor; microvessel density
资金
- NCI NIH HHS [P30 CA062203] Funding Source: Medline
Angiogenesis, the formation of blood vessels, is necessary for a tumor to grow, but when angiogenesis first appears in the progression of breast ductal carcinomas is unknown. To determine when this occurs, the authors examined microvessel density (MVD) by CD31 and CD105 immunostaining in normal ducts, 32 cases of usual hyperplasia, 19 cases of atypical hyperplasia, and 29 cases of ductal carcinoma in situ (DCIS). Simple hyperplasia had a 22-fold greater MVD than normal ducts (P < .0001). An increase during the progression of ductal changes was highly significant (P < .0001). To determine a possible mechanism, immunohistochemistry for vascular endothelial growth factor (VEGF) was evaluated. VEGF staining intensity of ductal epithelium increased during the progression from normal to hyperplastic to DCIS. This study shows that the first significant increase in angiogenesis occurs very early in the evolution of ductal proliferations as ductal cells become hyperplastic.
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