期刊
MOLECULAR IMMUNOLOGY
卷 63, 期 1, 页码 9-17出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2014.01.018
关键词
Mast cells; Mast cell progenitors; Development; Recruitment; Mouse
资金
- Swedish Research Council
- Swedish Heart-Lung Foundation
- Malin and Lennart Philipson Foundation
- Bror Hjerpstedts Foundation
- Agnes and Mac Rudberg Foundation
- Lennander Foundation
- Ellen, Walter and Lennart Hesselman Foundation
Mast cells in tissues are developed from mast cell progenitors emerging from the bone marrow in a process highly regulated by transcription factors. Through the advancement of the multicolor flow cytometry technique, the mast cell progenitor population in the mouse has been characterized in terms of surface markers. However, only cell populations with enriched mast cell capability have been described in human. In naive mice, the peripheral tissues have a constitutive pool of mast cell progenitors. Upon infections in the gut and in allergic inflammation in the lung, the local mast cell progenitor numbers increase tremendously. This review focuses on the origin and development of mast cell progenitors. Furthermore, the evidences for cells and molecules that govern the migration of these cells in mice in vivo are described. (C) 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
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