期刊
MOLECULAR IMMUNOLOGY
卷 64, 期 2, 页码 313-323出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2014.12.014
关键词
Generalized plaque type psoriasis; DNA methylation; Micro RNA; Histone modifications; Single nucleotide polymorphism; Genome-wide association study
资金
- Indian Statistical Institute
- CSIR
Psoriasis is a chronic inflammatory skin disease whose prevalence varies among different populations worldwide. It is a complex multi-factorial disease and the exact etiology is largely unknown. Family based studies have indicated a genetic predisposition; however they cannot fully explain the disease pathogenesis. In addition to genetic susceptibility, environmental as well as gender and age related factors were also been found to be associated. Recently, imbalances in epigenetic networks are indicated to be causative elements in psoriasis. The present knowledge of epigenetic involvement, mainly the DNA methylation, chromatin modifications and miRNA deregulation is surveyed here. An integrated approach considering genetic and epigenetic anomalies in the light of immunological network may explore the pathogenesis of psoriasis. (C) 2015 Elsevier Ltd. All rights reserved.
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