期刊
INTERNATIONAL JOURNAL OF STD & AIDS
卷 21, 期 1, 页码 57-59出版社
ROYAL SOC MEDICINE PRESS LTD
DOI: 10.1258/ijsa.2009.009164
关键词
HIV; syphilis; AIDS; mortality; cohort
资金
- Uniformed Services University of the Health Sciences (USUHS)
- HHS/NIH/NIAID/DCR [HU0001-05-2-0011]
- National Cancer Institute, National Institutes of Health [HHSN261200800001E]
- National Institute of Allergy and Infectious Diseases
HIV and syphilis are often seen as co-infections since they share a common mode of transmission. During episodes of syphilis, CD4 counts transiently decrease and HIV viral loads increase; however, the effect of syphilis co-infection on HIV disease progression (time to AIDS or death) is unclear. We analysed prospectively collected information on 2239 persons with estimated dates of HIV seroconversion (205 [9.2%] with confirmed syphilis and 66 [2.9%] with probable syphilis) in order to determine the effect of syphilis co-infection on HIV disease progression. In multivariate models censored at highly active antiretroviral therapy (HAART) initiation or last visit, adjusting for CD4 count, age, race, gender, and hepatitis B and C status, syphilis (confirmed + probable) was not associated with increased hazard of AIDS or death (hazard ratio 0.99, 95% CI 0.73-1.33). Treating HAART as a time-varying covariate or limiting the analysis to only confirmed syphilis cases did not significantly alter the results. Despite transient changes in CD4 counts and viral loads, syphilis does not appear to affect HIV disease progression.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据