期刊
INTERNATIONAL JOURNAL OF STD & AIDS
卷 19, 期 3, 页码 208-210出版社
SAGE PUBLICATIONS LTD
DOI: 10.1258/ijsa.2007.007185
关键词
human immunodeficiency virus; hepatitis C; viral disease
Hepatitis C (HCV) treatment using interferon-alpha (IFN-alpha) and ribavirin is recommended in HlV/HCV co-infected patients to prevent liver cirrhosis and liver-related death. However, in addition to its antiviral activity, IFN is a pleiotropic cytokine able to synergistically amplify T-cell autoreactivity. Here, we report for the first time the induction of a subfulminant autoimmune hepatitis (AIH) after four months of a successful treatment of HCV-1b infection using peg-IFN and ribavirin, in a 48-year-old woman co-infected with HIV. Diagnosis was assessed according to the international AIH scoring system, including liver biopsy and confirmed by positive response to steroid challenge.
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